Regulation of basal myocardial function by NO

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Regulation of basal myocardial function by NO.

The effects of exogenous and endogenous. NO on myocardial functions such as contraction, relaxation and heart rate have recently gained considerable scientific interest. .NO stimulates myocardial soluble guanylate cyclase to produce cGMP, which activates two major target proteins. A small increase in cGMP levels predominantly inhibits phosphodiesterase III, while high cGMP levels activate cGMP-...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 1999

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(98)00314-9